Please contact your Administrator to change your authorization settings.
| Recruitment/Posting Title | Post-Doc Associate - Barr Lab |
|---|---|
| Department | Human Genetics Inst of NJ |
| Salary | Commensurate With Experience |
| Posting Summary | This is an NIH-funded postdoctoral research position. The long-term goal of this research project is to understand how cilia function. Cilia and extracellular vesicles (EVs) are signaling organelles that play important roles in human health and disease. We recently showed that C. elegans ciliated sensory neurons release bioactive, polycystin-containing EVs. In humans, mutations in the polycystin-encoding PKD1 and PKD2 genes cause autosomal dominant polycystic kidney disease (ADPKD). In C. elegans and mammals, the polycystins act in the same genetic pathway, act in a sensory capacity, localize to cilia, and are contained in secreted EVs, indicating ancient functions. EV shedding from ciliated cells is an evolutionarily conserved phenomenon, yet remarkably little is known about the relationship between the polycystins, cilia, and EVs and the fundamental biology of EVs. The primary role of this position is to design, perform, and interpret experiments to address central questions regarding the biology of cilia, EVs, and the polycystins. |
| Position Status | |
| Posting Number | 19FA1633 |
| Posting Open Date | |
| Posting Close Date |
| Minimum Education and Experience | PhD and some postdoctoral experience |
|---|---|
| Certifications/Licenses | |
| Required Knowledge, Skills, and Abilities | Required professional experience includes biochemistry (sucrose gradient fractionation, mRNA isolation and quantification, immunodetection of protein abundance, analytical biochemistry of lipids, carbohydrates, and amino acids); animal physiology (breeding and genotyping, neurological and behavioral analysis); molecular biology (gene engineering and cloning, analytical purification of nucleic acids in agarose and polyacrylamide gels, protein expression and purification. Analytical in vitro kinase, protease, and nuclease assays. In house preparation of in vitro translation systems from eukaryotic cells, use of the Firefly and Renilla luciferase reporter gene expression systems); bioinformatics (library preparation for RNASeq. Complete processing of raw sequencing files to reveal differentially expressed genes). |
| Equipment Utilized | |
| Physical Demands and Work Environment | |
| Overview | Research: Independent research and experimentation inclulding injections/transgenesis, C. elegans genetics, molecular biology, microscopy (dissecting, epifluorescence/Nomarski, confocal, time lapse), biochemistry, behavioral assays. Writing: manuscripts on results and interpretations of research projects; fellowship/grant applications to obtain independent funding. Lab responsibilities including routine lab maintenance and/or supervising trainees |
| Statement |
| Special Instructions to Applicants | |
|---|---|
| Quick Link to Posting | |
| Campus | Rutgers University-New Brunswick |
| Home Location Campus | Busch (RU-New Brunswick) |
| City | |
| State | |
| Location Details | Life Science Building |
Under Policy 100.3.1 , if employment will commence during Flu Season, Rutgers University may require certain prospective employees to provide proof that they are vaccinated against Seasonal Influenza for the current Flu Season, unless the University has granted the individual a medical or religious exemption. Additional infection control and safety policies may apply. Prospective employees should speak with their hiring manager to determine which policies apply to the role or position for which they are applying. Failure to provide proof of vaccination for any required vaccines or obtain a medical or religious exemption from the University will result in rescission of a candidate's offer of employment or disciplinary action up to and including termination.
It is university policy to provide equal employment opportunity to all its employees and applicants for employment regardless of their race, creed, color, national origin, age, ancestry, nationality, marital or domestic partnership or civil union status, sex, pregnancy, gender identity or expression, disability status, liability for military service, protected veteran status, affectional or sexual orientation, atypical cellular or blood trait, genetic information (including the refusal to submit to genetic testing), or any other category protected by law. As an institution, we value diversity of background and opinion, and prohibit discrimination or harassment on the basis of any legally protected class in the areas of hiring, recruitment, promotion, transfer, demotion, training, compensation, pay, fringe benefits, layoff, termination or any other terms and conditions of employment. For additional information please see the Non-Discrimination Statement at the following web address: http://uhr.rutgers.edu/non-discrimination-statement